- Title
- Androgen receptor is dispensable for x-zone regression in the female adrenal but regulates post-partum corticosterone levels and protects cortex integrity
- Creator
- Gannon, Anne-Louise; O'Hara, Laura; Mason, Ian J.; Jørgensen, Anne; Frederiksen, Hanne; Curley, Michael; Milne, Laura; Smith, Sarah; Mitchell, Rod T.; Smith, Lee B.
- Relation
- Frontiers in Endocrinology Vol. 11, Issue January 2021, no. 599869
- Publisher Link
- http://dx.doi.org/10.3389/fendo.2020.599869
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2021
- Description
- Adrenal androgens are fundamental mediators of ovarian folliculogenesis, embryonic implantation, and breast development. Although adrenal androgen function in target tissues are well characterized, there is little research covering the role of androgen-signaling within the adrenal itself. Adrenal glands express AR which is essential for the regression of the X-zone in male mice. Female mice also undergo X-zone regression during their first pregnancy, however whether this is also controlled by AR signaling is unknown. To understand the role of the androgen receptor (AR) in the female adrenal, we utilized a Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.
- Subject
- adrenal cortex; x-zone; androgen receptor; spindle cell; hyperplasia
- Identifier
- http://hdl.handle.net/1959.13/1456301
- Identifier
- uon:45206
- Identifier
- ISSN:1664-2392
- Rights
- © 2021 Gannon, O’Hara, Mason, Jørgensen, Frederiksen, Curley, Milne, Smith, Mitchell and Smith. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2124
- Visitors: 2183
- Downloads: 65
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 9 MB | Adobe Acrobat PDF | View Details Download |